5 Mar 2021 ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include

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Adiponectin may have relevance for energy metabolism through the regulation of fatty acid oxidation. A number of studies have suggested that adiponectin plays a regulatory role in atherogenesis, endothelial function, and vascular remodeling. 1-10 Adiponectin is also involved in the inflammatory process and is of importance in the appearance of arteriosclerosis and coronaritis. Recombinant Human Adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest116: 1784–1792.

Adiponectin may have relevance for energy metabolism through the regulation of fatty acid oxidation. A number of studies have suggested that adiponectin plays a regulatory role in atherogenesis, endothelial function, and vascular remodeling. 1-10 Adiponectin is also involved in the inflammatory process and is of importance in the appearance of arteriosclerosis and coronaritis.

Adiponectin (APN) is a unique adipokine with multiple salutary effects such as antiapoptotic, anti-inflammatory, and anti-oxidative activities in numerous organs and cells. Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2.

Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation of glucose and lipid metabolism. Adiponectin also possesses insulin-sensitizing, anti-inflammatory, angiogenic, and vasodilatory properties which may influence central nervous system (CNS) disorders.

Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Adiponectin is a hormone secreted from white adipocytes and takes part in the regulation of several metabolic processes.

58 Consistent with these in vitro findings, overexpression of adiponectin protects against the development of Adiponectin wird durch das ADIPOQ-Gen auf Chromosom 3 (Genlokus 3q27.3) kodiert. 3 Biochemie. Adiponectin ist ein Protein aus 244 Aminosäuren, das Trimere bildet, die sich weiter zu Hexameren oder Dodekameren zusammenlagern. Es hat ein Molekulargewicht von 28 kDa. Mouse monoclonal Adiponectin antibody [19F1].
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No iterations to show. Adiponectin.

It also stimulates glucose uptake in myocytes (3). Adiponectin, exclusively secreted from adipose tissue, has been postulated to decrease the risk for insulin resistance, inflammation, type 2 diabetes, and cardiovascular disease. Adiponectin is increased after treatment with a subset of antihypertensive drugs and may partially mediate these beneficial effects.
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest116: 1784–1792. Kadowaki T, Yamauchi T, Kubota N (2008). The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett582: 74–80.

Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptor … Adiponectin also improves β-cell function. Adiponectin increases glucose-mediated insulin secretion and transcription of insulin. Plasma adiponectin levels are associated with β-cell function and the risk of developing type 2 diabetes in humans.

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Abstract : Adiponectin is a protein secreted from adipocytes, circulating at high levels in plasma (3 30μg/mL), and in overweight subjects it is down regulated.

Adiponectin binding to Adipo R1 causes a calcium influx in skeletal muscle that activates CaMKK beta. Activated CaMKK beta induces the expression and activation of PGC1 alpha via a cascade involving the activation of AMPK and increased production of the SIRT1 deacetylase.